Table 1.

Concomitant Drug Therapy and Situations for Which There Are In Vivo Data, Either in Adult Humans or Animals, for Increased Susceptibility to Acetaminophen Toxicity

Human
Carbamazepine induction of CYP45032,33
Ethanol18,31
Isoniazid30,34,35
Phenobarbital36–38
Rifampin35
Prolonged fasting5,18
Animal
Dexamethasone39
Doxorubicin40
Prolonged fasting19–21