Table 5.

Drugs That Have Been Associated With Significant Effects on Some Nursing Infants and Should Be Given to Nursing Mothers With Caution*

DrugReported EffectReference No.
AcebutololHypotension; bradycardia; tachypnea116
5-Aminosalicylic acidDiarrhea (1 case)117–119
AtenololCyanosis; bradycardia120–124
BromocriptineSuppresses lactation; may be hazardous to the mother125, 126
Aspirin (salicylates)Metabolic acidosis (1 case)127–129
ClemastineDrowsiness, irritability, refusal to feed, high-pitched cry, neck stiffness (1 case)130
ErgotamineVomiting, diarrhea, convulsions (doses used in migraine medications)131
LithiumOne-third to one-half therapeutic blood concentration in infants132–134
PhenindioneAnticoagulant: increased prothrombin and partial thromboplastin time in 1 infant; not used in United States135
PhenobarbitalSedation; infantile spasms after weaning from milk containing phenobarbital, methemoglobinemia (1 case)136–140
PrimidoneSedation, feeding problems136, 137
Sulfasalazine (salicylazosulfapyridine)Bloody diarrhea (1 case)141
  • * Blood concentration in the infant may be of clinical importance.