Table 1.

Cytotoxic Drugs That May Interfere With Cellular Metabolism of the Nursing Infant

DrugReason for Concern, Reported Sign or Symptom in Infant, or
Effect on Lactation
Reference No.
CyclophosphamidePossible immune suppression; unknown effect on growth or
association with carcinogenesis; neutropenia
26, 27
CyclosporinePossible immune suppression; unknown effect on growth or
association with carcinogenesis
28, 29
Doxorubicin* Possible immune suppression; unknown effect on growth or
association with carcinogenesis
30
MethotrexatePossible immune suppression; unknown effect on growth or
association with carcinogenesis; neutropenia
31
  • * Drug is concentrated in human milk.