TABLE 2

Number of Pediatric Trials and Participants and Pediatric Global Burden of Disease According to Condition

ConditionAll Trials, n (N = 4619)RCTs, n (N = 3246)Drug RCTs, n (N = 1369)Randomized Participants, na,b (N = 1 342 049)Global Burden of Disease in DALYs (Rank)
Neuropsychiatric conditions874642267103 13448 940 526 (5)
Nonrespiratory infections and parasitic diseases847637188636 471182 759 532 (1)
Perinatal conditions523430152179 933126 420 651 (2)
Malignant neoplasms4731237765 1994 110 685 (14)
Respiratory diseases36629018670 85610 691 264 (8)
Respiratory infections24721182127 57977 264 822 (3)
Digestive diseases2081377416 7577 695 304 (9)
Diabetes mellitus1381174914 935542 738 (20)
Congenital anomalies129895310 40624 256 090 (7)
Musculoskeletal diseases128863811 1892 489 737 (17)
Nutritional deficiencies106931442 30627 844 589 (6)
Unintentional injuries101762610 06452 837 234 (4)
Cardiovascular diseases96673213 4976 683 866 (11)
Genitourinary diseases96624367511 888 187 (18)
Sense organ diseases77502075006 024 722 (12)
Skin diseases67422935311 064 523 (19)
Oral conditions63551612 0622 532 862 (16)
Endocrine disorders62292236543 682 728 (15)
Nonmalignant neoplasms931422372 642 (21)
Intentional injuries55054797 130 242 (10)
Maternal conditions4203245 270 155 (13)
  • a Excluding subjects enrolled in trials with cluster randomization.

  • b Enrollment figures missing for 5 trials: 1 each in infectious diseases, perinatal conditions, nutritional deficiencies, childhood cluster diseases, and sense organ diseases.