TABLE 4

Bivariate and Multivariate Analyses of Factors Significantly Associated With Being Very Likely to Recommend Rotavirus Vaccine Versus All Others (N = 299)

FactorsUnadjusted OR (95% CI)Adjusted OR (95% CI)
Demographicsa
Practice setting
    PrivateRef
    HMO/MCO2.97 (1.03–8.60)
    Public or community health center / University or hospital based practice1.85 (0.88–3.86)
Knowledge, attitudes and beliefs
    Strongly agree with “Because rotavirus infections are common and potentially severe in the U.S., there is a need for a safe and effective rotavirus vaccine.”5.96 (3.61–9.82)5.81 (3.24–10.41)
    Administered RotaShield routinely to all eligible patients prior to withdrawal of the RotaShield vaccine2.49 (1.57–3.97)
    Will routinely discuss with parents and young patients the association between the previously licensed rotavirus vaccine and intussusception0.64 (0.40–1.01)
    Have a great deal of confidence in pre-licensure studies (prior to FDA approval) in determining vaccine safety5.81 (3.11–10.88)4.13 (2.02–844)
    Have a great deal of confidence in post-licensure surveillance (VAERS and other safety mechanisms) to monitor vaccine safety2.25 (1.41–3.59)
Barriers to vaccinationb
    Physician concerns about the safety of the rotavirus vaccine0.15 (0.08–0.31)0.22 (0.01–0.51)
    Parents’ reluctance to have their child vaccinated because of the withdrawal of the previous rotavirus vaccine0.45 (0.27–0.77)
    Parents’ concerns about vaccine safety in general0.22 (0.11–0.47)0.27 (0.11–0.67)
    Parents’ not thinking that a rotavirus vaccine is necessary0.35 (0.16–0.77)
    Physician belief that rotavirus is not a severe disease that requires a vaccination0.14 (0.03–0.65)
    Time it will take for physician to discuss rotavirus vaccine safety with parents0.10 (0.01–0.83)
    Up-front costs for physician practice to purchase the vaccine0.41 (0.23–0.74)
    Physician concerns about adding another vaccine to an already overloaded vaccine schedule0.17 (0.06–0.50)
  • OR indicates odds ratio; CI, confidence interval; HMO, health maintenance organization; MCO, managed care organization; Ref, reference; —, not significant in adjusted analysis.

  • a The following demographics were not significant in the bivariate analysis: gender, age of physician, practice location, region of the country, an physician participating in VFC.

  • b The following variables pertaining to physicians’ knowledge, attitudes, and beliefs and perceived barriers were not significant in the bivariate analysis: physicians’ awareness in their practice or in their community regarding those who had intussusception suspected to be associated with RotaShield use; difficulty obtaining adequate vaccine supplies; lack of adequate reimbursement for vaccination; failure for some insurance companies to cover vaccination; and general administrative burden to physicians’ practice.