Levels of Evidence59

Recommendation LOELOEGrade of Recommendation
Preterm infants born at <30 wk of gestation who need mechanical ventilation because of severe RDS should be given surfactant after initial stabilization.1Strong Recommendation
Using CPAP immediately after birth with subsequent selective surfactant administration should be considered as an alternative to routine intubation with prophylactic or early surfactant administration in preterm infants.1Strong Recommendation
Rescue surfactant may be considered for infants with hypoxic respiratory failure attributable to secondary surfactant deficiency (eg, meconium aspiration syndrome or sepsis/pneumonia).2Recommendation