Table 1.

Mean Water Diffusion Measures in Developing WM of Premature Infants With and Without WM Injury

Diffusion MeasureWM Regions
Internal CapsuleCentral WMFrontal WMOccipital WMTemporal WM
ADC (μm2/ms ± SD)
 No WM injury1.0 ± 0.11.5 ± 0.21.7 ± 0.11.6 ± 0.21.4 ± 0.1
 WM injury1.1 ± 0.11.5 ± 0.21.7 ± 0.11.5 ± 0.21.2 ± 0.5
PvalueNSNSNSNSNS
RA (% ± SD)
 No WM injury22.8 ± 4.712.9 ± 3.38.2 ± 1.49.1 ± 1.013.9 ± 1.8
 WM injury17.2 ± 3.99.5 ± 1.79.0 ± 1.47.7 ± 1.811.9 ± 2.2
Pvalue.02.03.3.06.7
  •  Comparison of ADC and RA (%) measured in different WM regions and in posterior limb of internal capsule in 2 groups (n= 10 in each group as described in “Methods”) of preterm infants at term. No significant differences in ADC values are observed between preterm infants with or without perinatal WM injury. By contrast, RA values are significantly reduced in the internal capsule and the central WM in preterm infants with perinatal WM injury compared with preterm infants at term with no perinatal WM injury. Occipital WM shows a tendency to lower RA values.