Table 1.

Quantitative 3D-MRI Volumes of Cerebral Tissues at Term in Premature Infants Treated With Dexamethasone for Neonatal Chronic Lung Disease, Premature Infants Never Treated With Dexamethasone, and Healthy Term Infants

Brain RegionVolume (mL)*
Premature at Term
DEX (n = 7)
Premature at Term
No DEX (n = 11)
Healthy Term
(n = 14)
ANOVA Pairwise Multiple Comparisons
Cerebral cortical gray matter130.3 ± 54.0200.6 ± 35.1218.8 ± 21.3<0.001
Basal ganglia/thalamus23.2 ± 13.225.5 ± 11.824.7 ± 8.90.91
Cerebrospinal fluid55.8 ± 19.660.1 ± 21.432.9 ± 13.50.87
Myelinated white matter9.6 ± 3.915.2 ± 8.527.6 ± 10.10.39
Unmyelinated white matter178.6 ± 27.3206.9 ± 41.1200.3 ± 32.90.25
Total cerebral tissue volume312 ± 43.7448 ± 50.2471 ± 34.60.001
Total intracranial volume397.5 ± 61.1508.2 ± 64.1503.5 ± 39.40.001
  • * Values are mean ± standard deviation.

    DEX indicates treated with dexamethasone.