TABLE 1

Number of Pediatric Trials and Participants and Pediatric Burden of Disease by Country Income Level

All Trials (N = 5373)RCTs (n = 3771)Drug RCTs (n = 1526)Randomized Participants (n = 1 466 689)Burden of Disease in DALYs
n%n%n%n%a,bn%
High-income countries426179288276117677889 4486113 569 7722
Middle-income countries746145681522515260 87918147 338 77325
Low-income countries366732181258316 36221439 382 26173
  • a Excluding subjects enrolled in trials with cluster randomization.

  • b Enrollment figures missing for 5 trials: 1 in middle-income level and 2 each in high- and low-income levels.