Table 5.

Progression of Multivariate Analyses From Epoch One (Day of Birth) Through Epoch Three (Days Four to Seven)

Most Parsimonious Models Ventilated Infants Only
Epoch 1Epoch 2Epoch 3
Day of birth (epoch 1)
 Maximum PIP >25,
 d of birth
2.2
(1.2, 3.9)
1.9
(1.0, 3.4)
1.9
(.9, 4.1)
 Maximum Fio2 = 1.0,
 d of birth
1.8
(1.1, 3.3)
1.7
(.92, 3.1)
1.0
(.5, 2.2)
Postnatal d 1–3 (epoch 2)
 Lowest PIP >20,
 d 1–3
2.6
(1.2, 5.1)
1.9
(.8, 4.9)
 Maximum Pco2 >50, d 1–32.5
(1.3, 5.0)
2.6
(1.1, 6.6)
Postnatal d 4–7 (epoch 3)
 Lowest WBC <8 K, d 4–72.9
(1.2, 6.9)
  • * ORs and 95% CIs are reported for each exposure variable. Bold indicates values that achieved statistical significance (P < .05).

  • All models are adjusted for pre/perinatal variables, including: gestational age <26 weeks, gestational age 26 to 28 weeks, magnesium sulfate infusion during labor, neonatal thyroxine level <5.3 μg/dL, and antenatal glucocorticoid treatment.