Table 4.

Summary of Evidence Tables for Newborn Screening Strategies*

Strategy (Arc)Positive Screen Rate per 1000 ExaminationsSample Size
Average (SD)
Sample Size
Total
No. of
Arms§
Unweighted
Average
(SD)
Weighted
Average
(SD)
Meta-analytic
Average
(SD)
Pediatric examination(1 → 3)8.7 (6.4)8 (4)8.6 (7.1)61 941 (170 647)2 044 05754
Orthopaedic examination (1 → 5)22 (60)7 (3.7)22 (28)26 342# (40 923) 740 60028
11.5** (11)11.4** (11)
Ultrasonographic examination (1 → 4)37.7 (55)25.4 (32)36 (39)2636 (2171)    44 80817
264-164 (27)224-164 (17)24.94-164 (23.5)
  • * See Evidence Tables 1, 2, and 3.

  • Arc refers to the influence diagram (see Fig. 2).

  • Weighted estimates computed by pooling the numerators and denominators of the target arms.

  • § Some studies involved more than 1 arm.

  • Only studies acknowledging 3 categories were included.

  • Without outliers (target article 21 [917 865 subjects] and target article 23 [415 542 subjects]), the mean (SD) is 22 924 (30 015).

  • # Excluding outliers (target article 43 [202 657 subjects] and target article 40 [108 966 subjects]), the mean (SD) is 16 499 (11 170).

  • ** Excluding an outlier (target article 104, with a rate of 325.3/1000).

  • F4-164 Without the outlier, target article 69 (224/1000).