TABLE 1

Incidence and Clinical Characteristics of Immunocompromised Children With IA

Underlying DiseaseNNo. of Cases of IA (n = 666)Incidence of IA, %
Malignancy99177492 (74%)0.5
    Solid tumor4302651 (8%)0.1
        Bone17505210.1
        CNS13710130.1
        Other11991170.14
    Leukemia33243381 (57%)1
        ALL269261710.6
        AML46921733.7
    Lymphoma813238 (6%)0.4
    Other malignancy (NOS)2539972 (11%)NA
Hematologic disorder (aplastic anemia)12829192 (28%)1.4
Immunodeficiency3733122 (18%)3.2
    Wiskott-Aldrich syndrome2678130
    Functional disease of neutrophils (CGD)322216.5
    Combined immunity deficiency41171.7
    HIV262690.3
    Congenital hypogammaglobulinemia11943.3
BMT3013103 (15%)3.4
    Allogeneic22191014.5
        GVHD1555764.9
        Non-GVHD664253.7
    Autologous82230.3
    NOS181NA
Solid-organ transplant15936 (1%)0.3
    Lung3925
    Heart27810.3
    Liver56930.5
  • NOS indicates not otherwise specified; NA, not available.