Table 3.

Important Influence of Sampling Strategy in Defining a Drug's Pharmacokinetic Profile: Propofol

ParameterData Presented as Mean (±SD)
Gepts
et al11
Raoof
et al12
Kantaria
et al13
Reed
et al14
n18 65349
Age (y)Adult1–3.63–11 0.01–16
Samplen16115–18 20
Sample duration (h) 8 4∼2.524
t1/2α (min)2.8 (1.2)23.5 (4)
t1/2β (min)31 (15)2738 (25)
t1/2γ (min)355 (227)100 (3)3291102.8 (106)
Vc(L/g)16.9 (7)0.320.67 (.07)
V2(L/g)1.01.6 (1.4)
V3(L/g)4.3 (3)2.4 (1.4)*5.930.3 (30)
Cl (mL/kg/min)26.738.7 (6.8)3755.8 (21)
  • t1/2 Indicates half-life during the α, β, and γ phases; V, volume of distribution for the central (C) and peripheral (2, 3) compartments.