TABLE 6

Sedation Failures and Adverse Events

PatientAge, yWt, kgReason for StudyStudyComorbidityMedication HistoryMedication ReceivedReason for Failure or Adverse Event
11080Precocious puberty, strabismusCranial MRISeizure disorder, developmental delay, phenobarbital allergyTopiramate, Keppra, carbamazepineF (50 μg) M (6 mg)Could not sedate
218.2Cerebellar lesionCranial MRIHydrocephalus, ventriculoperitoneal shuntF (20 μg) M (2 mg) P (32 mg)Could not sedate
30.57.5Torticollis, staring spellsCranial and neck MRINoneNoneCH (575 mg)Awake after cranial MRI; could not perform neck MRI
4212.2Left knee infectionMRI legKnee cellulitis with prepatellar bursitisNoneM (2.5 mg) P (36 mg) F (24 μg)Could not sedate
5614SeizureCranial MRIHistory of 1 seizureNoneM (2 mg) P (42 mg) F (14 μg)Experienced respiratory depression and hypoxia (O2 saturation 85%); required <5 min of assisted ventilation and 1 dose of naloxone; discharged by inpatient service within 24 h without event
6211.3Follow-up scanCranial MRILeft midbrain lesion; likely astrocytomaNonePropofol bolus 21 mg; Maximum infusion: 100 mg/hExperienced hypotension (BP 60/28) during propofol infusion; infusion rate was decreased, and a 30-mL crystalloid bolus was administered with resolution of hypotension; MRI was completed successfully
72.512.9Sinus tractMRI spineLumbosacral pit; gluteal cellulitis, seizures, diabetes insipidus, microcephalyZonisamide, valproic acid, DDAVP, Claritin, clindamycinM (1 mg) F (10 μg)O2 saturations decreased to 90%, with respiratory distress; MRI was rescheduled the following day and completed successfully without event
  • F indicates fentanyl; M, midazolam; P, pentobarbital; CH, chloral hydrate; BP, blood pressure.