Table 3.

Preimmunization and Postimmunization Geometric Mean Proliferation (95% CI) and CMI Response Rates of Groups Receiving dTpa or Td + pa*

VariableVaccine Group
dTpa (n = 110)Td (n = 12)pa (n = 12)
Pertussis toxin
 Pre-GMP(cpm)840 (665–1061)644 (246–1687)503 (240–1053)
 Post-GMP7969 (6984–9092)503 (240–1053)8950 (6087–13161)
 Pre-CMI+ (%)4642 42
 Post-CMI+9842100
Filamentous hemagglutinin
 Pre-GMP (cpm)590 (461–755)637 (250–1627)473 (220–1015)
 Post-GMP5903 (5117–6808)473 (220–1015)7601 (5144–11232)
 Pre-CMI+ (%)3533 33
 Post-CMI+9633100
Pertactin
 Pre-GMP (cpm)402 (328–494)404 (192–851)324 (163–643)
 Post-GMP3333 (2852–3895)§324 (163–643)5578 (4196–7414)§
 Pre-CMI+ (%)2425 25
 Post-CMI+8825100
Spontaneous proliferation
 Pre-GMP (cpm)223 (189–263)221 (129–381)207 (121–352)
 Post-GMP228 (199–261)207 (121–352)202 (129–317)
  • * The pa vaccine was given 1 month after the Td vaccine to the same subjects.

  • Pre-GMP indicates preimmunization geometric mean proliferation value.

  • CMI+ indicates a CMI response was defined positive when antigen-induced proliferation was at least fourfold higher than spontaneous proliferation.

  • § P < .003 between dTpa and pa groups.