Table 3.

Occurrence of High-Dose (in General Daily 6 mg) Folic Acid Supplementation in the Case-Control Pairs of Isolated CL ± CP and Isolated CP Groups, in Addition Distribution of Gestational Months According to the Start of Folic Acid Supplementation and Cumulative Number of Pregnant Women During the Critical Period of CL ± CP, ie, on 49 to 64 Gestational Days and of Cleft Palate, ie, on 70 to 98 Gestational Days in Case-Control Pairs of CL ± CP and CP Groups and Adjusted OR With 95% CI for Confounding Factors

Gestational MonthCL ± CP (n = 1246)OR (95% CI)CP (n= 537)OR (95% CI)
CasesControlsCasesControls
Number%Number%Number%Number%
I463.7655.2101.9132.4
II685.5897.1I–II = .72 (.55–.92)254.7458.4
III22418.022017.7I–III = .87 (.73–1.03)10018.69317.3I–III = .86 (.66–1.13)
IV937.51078.6387.15810.8I–IV = .75 (.58–.96)
V917.3917.3326.0417.6
VI383.0574.6IV–IX = .90 (.75–1.08)193.5224.1
VII352.8352.8244.5122.2V–IX = .99 (.71–1.38)
VIII231.8151.25.961.1
IX5.44.31.210.2
Total62350.068354.8I–IX = .82 (.70–.97)25447.3291*54.2I–IX = .76 (.60–.96)
Folic acid alone16313.117814.36712.57413.7
  • * The start of folic acid supplementation was unknown is 1 control.