Table 2B.

Extrapolating Pediatric Dosing From Adults—Theophylline, Paradigm for Hepatic Metabolism

Extrapolated dosing
 Weight-adjusted10 mg/kg/d
 BSA-adjusted20 mg/kg/d
Recommended dosing
 Preterm neonate 3 mg/kg/d
 Infants10 mg/kg/d
 6–12 mo12–18 mg/kg/d
 1–9 y20–24 mg/kg/d
 9–12 y16 mg/kg/d
 12–16 y13 mg/kg/d