Table 3.

Oral Challenge in 18 Children With Negative Skin Test Results to β-Lactams

CasesClinical Symptoms
(Drugs)
ChronologyOC Positive
With (Chronology)
Oral Challenge
Negative With
Anaphylaxis
25Angioedema + palmoplantar pruritus (amoxicillin)ImmediateAmoxicillin (immediate urticaria and angioedema)Cefixime
MPR (cephatrizine)Delayed
26Urticaria + laryngeal edema (amoxicillin)AcceleratedAmoxicillin (immediate urticaria and angioedema)ND (treatments tolerated with cephalosporins)
27Laryngeal edema (amoxicillin)AcceleratedAmoxicillin-clavulanic acid (immediate angioedema)Amoxicillin
Urticaria + angioedema (amoxicillin-clavulanic acid)Delayed
Mild to moderate urticaria or angioedema
28Urticaria (amoxicillin)AcceleratedAmoxicillin (delayed urticaria)Cefixime
Urticaria (cefatrizine)Accelerated
29Urticaria (amoxicillin)DelayedAmoxicillin (delayed urticaria)Cefixime
30Urticaria (cefixime)DelayedCefixime (accelerated urticaria)Cefaclor, cefpodoxime
Unidentified rash (cefaclor)Delayed
31Urticaria (amoxicillin-clavulanic acid)AcceleratedAmoxicillin-clavulanic acid (accelerated urticaria)Amoxicillin
32Angioedema (cefaclor)AcceleratedAmoxicillin (delayed angioedema)Cefixime
Angioedema (amoxicillin)Accelerated
33Urticaria + angioedema (amoxicillin)DelayedAmoxicillin (delayed urticaria)ND (treatments tolerated with cefuroxime)
34Urticaria + angioedema (amoxicillin-clavulanic acid)AcceleratedAmoxicillin-clavulanic acidAmoxicillin-clavulanic acid tablets
Urticaria + angioedema (cephadroxil)AcceleratedSuspension (accelerated urticaria and angioedema)
35Angioedema (amoxicillin-clavulanic acid)AcceleratedAmoxicillin-clavulanic acid and cefpodoxime suspensions (delayed angioedema)Amoxicillin-clavulanic acid tablets
Angioedema (cefixime)Accelerated
Angioedema (cefpodoxime)Accelerated
Other reactions
36Unidentified rash (amoxicillin suspension)AcceleratedAmoxicillin tablets (accelerated morbilliform rash)Cefixime
37Unidentified rash (amoxicillin-clavulanic acid)DelayedAmoxicillin (accelerated morbilliform rash)ND (treatments tolerated with cephalosporins)
38Unidentified rash (amoxicillin)AcceleratedAmoxicillin (delayed urticaria)Cefpodoxime
Unidentified rash (cefaclor)Accelerated
39Unidentified rash (amoxicillin)AcceleratedAmoxicillin (delayed urticaria and angioedema)Cefpodoxime
40Unidentified rashes (amoxicillin-clavulanic acid)AcceleratedAmoxicillin-clavulanic acid (delayed urticaria)Amoxicillin
41Unidentified rash (cephadroxyl)DelayedCefadroxyl suspension (delayed morbilliform rash)Cephadroxyl tablets
42SSLR (amoxicillin-clavulanic acid)DelayedCefixime (delayed urticaria)ND
  • ND indicates not done.