Table 2.

Case Histories of 24 Children With Positive Skin Test Results to β-Lactams (n = 22) or Cutaneous Reactions Induced by Skin Tests (n = 2)

CasesClinical Symptoms
(Drugs)
ChronologyPositive Skin
Test Results
Negative OC
Test Results
Anaphylaxis
 1Urticaria + respiratory distress (amoxicillin)ImmediatePenicillin G, amoxicillin, cefazolin, cefotaximeND
 2Shock with laryngeal edema (cefatrizine)ImmediateAmoxicillin, cefazolinCefixime
 3Shock (cefaclor)ImmediateAmoxicillin, cefazolinCefpodoxime
 4Shock (cefatrizine)ImmediateCefazolin, cefotaximeAmoxicillin
 5Urticaria + laryngeal edema (cefatrizine)ImmediateCefazolinAmoxicillin
 6Urticaria + laryngeal edema (cefatrizine)ImmediateCefazolinAmoxicillin
 7Urticaria + laryngeal edema (cefatrizine)ImmediateCefazolinND*
 8Severe faintness + angioedema (cefatrizine)ImmediateCefazolin, cefotaximeAmoxicillin
 9Urticaria + laryngeal edema (cefixime)DelayedCefotaximeAmoxicillin
10Urticaria + laryngeal edema (amoxicillin)DelayedAmoxicillin, cefotaximeND
11Urticaria + laryngeal edema (cefaclor)DelayedCefazolinND*
12Angioedema + respiratory distress (amoxicillin + clavulanic acid)DelayedAmoxicillin Cefixime
Mild to moderate urticaria or angioedema
13Angioedema (amoxicillin)AcceleratedAmoxicillin, cefotaximeND
14Urticaria (cefpodoxime)AcceleratedCefotaximeAmoxicillin
15Angioedema (cefixime)AcceleratedCefotaximeAmoxicillin
16Angioedema (amoxicillin)AcceleratedAmoxicillinND*
17Urticaria (cefixime)AcceleratedCefotaximeAmoxicillin
18Urticaria + angioedema (cefadroxil)AcceleratedCefazolin Amoxicillin
19Urticaria + angioedema (cefatrizine)AcceleratedCefazolin Amoxicillin and cefpodoxime
20Urticaria + angioedema (amoxicillin)Accelerated and delayedAmoxicillin ND*
21Urticaria + angioedema (amoxicillin)DelayedAmoxicillin ND*
22Urticaria (cefadroxil)DelayedCephalotinOracillin, amoxicillin
Other reactions
23Unidentified rash (cefaclor)DelayedAmoxicillin, cefazolinND
24Unidentified rash (amoxicillin)DelayedAmoxicillin, cefotaximeND
  • ND indicates not done.

  • * No reaction with nonsuspected betalactams since the (most recent) reaction.

  • Immediate response negative, only accelerated and delayed skin tests positive.

  • Negative skin test results, but accelerated urticaria following skin tests.