Table 4.

Diagnosis of Allergy to β-Lactam Antibiotics in 68 Children,n (%)

SymptomsDiagnostic MethodTotal
Responses to
Skin Tests
Oral ChallengeClinical History
Severe anaphylaxis12  (34.3%)3  (8.6%)15/35  (42.9%)
Urticaria and/or angioedema10*  (5.7%)6  (3.4%)16/175  (9.1%)
SSLR1 1616/16
Toxidermias1414/14
Unidentified rashes2  (2.7%)5  (6.7%)7/75  (9.4%)
Total24/325  (7.4%)15/325  (4.6%)29/325  (8.9%)68/325  (20.9%)
  • * Including 2 children with negative skin test results but accelerated urticaria after skin testing.

  • One child diagnosed as allergic on the basis of clinical history (severe SSLR to amoxicillin + clavulanic acid) and with positive OC test results with cefixime.