TABLE 1

Clinical, Laboratory, and Instrumental Findings in Symptomatic Congenitally CMV-Infected Newborns

FindingsNo. Positive/No. Total (%)
Prematurity8/22 (36)
Intrauterine growth restriction5/22 (22.7)
Petechiae-purpura5/22 (22.7)
Hepatosplenomegaly5/22 (22.7)
Neurologic involvement
    ≥1 of the following signs10/22 (45.4)
        Microcephaly7/22 (31.8)
        Seizures, motor or postural abnormalities2/22 (9)
        Chorioretinitis1/21 (4.7)a
Aortic thrombosis1/22 (4.5)
Neonatal hydrops1/22 (4.5)
Elevated ALT (>80 U/L)4/22 (18.2)
Hyperbilirubinemia (direct bilirubin ≥3 mg/dL)0/22 (0)
Thrombocytopenia
    Platelet count, <100 000/mm39/22 (41)
    Platelet count, <50 000/mm34/22 (18.2)
Neuroimaging abnormalities
    ≥1 of the following14/21 (66.6)a
        Cerebral calcifications9/21 (42.8)a
        Ventriculomegaly8/21 (38)a
        Otherb5/21 (23.8)a
Hyperechoic bowel1/22 (4.5)
  • a One newborn died before the evaluation.

  • b Periventricular cysts (2 cases), hyperechogenicity of lenticolo-striatal vessels (1 case), intraventricular hemorrhage grade 1 in a term newborn (1 case), and periventricular radiolucencies (1 case).