Table 1.

Indications for Allogeneic and Autologous Stem Cell Support*

DiseaseAllogeneic TransplantationAutologous Transplantation
Leukemia (acute lymphoblastic, acute myelogenous, chronic myelogenous)EffectiveControversial; no better than conventional therapy
Lymphomas (Hodgkin disease, non-Hodgkin lymphoma)EffectiveUsed rarely and only when marrow not involved
Neuroblastoma (stage IV)Controversial; studies ongoing to define role related to conventional therapy and autologous transplantationControversial; studies ongoing to define role related to conventional therapy and allogeneic transplantation
Bone and soft tissue sarcomas, Wilms tumor, brain tumorsVery rarely indicatedRarely indicated and effectiveness unproven
Aplastic anemia and other cytopenias (not environmentally caused)EffectiveNot indicated
Immune deficiency (eg, severe combined immunodeficiency disease)EffectiveNot indicated
Hemoglobinopathies, thalassemia, sickle cell anemiaEffectiveNot indicated
Metabolic storage disorders, Hurler syndrome, metachromatic leukodystrophyControversial; may be effective in selected patientsNot indicated
  • * See reference 3 in this article.