TABLE 2.

Perinatal, Sociodemographic, and Developmental Characteristics of the Responders: T4 Versus Placebo Group

T4 (N = 58)Placebo (N = 55)P
Prerandomization
    Female gender, n (%)28 (48)30 (55).505
    Race, white, n (%)49 (85)52 (95).083
    Maternal education.965
        Low, n (%)17 (29)17 (31)
        Average, n (%)31 (53)27 (49)
        Above average, n (%)10 (17)11 (20)
    Gestational age ± SD, d197 ± 9197 ± 9.609
    Gestational age, wk.574
        25/26, n (%)10 (17)12 (22)
        27, n (%)12 (21)10 (18)
        28, n (%)14 (24)15 (27)
        29, n (%)22 (38)18 (33)
    Birth weight ± SD, g1113 ± 2251111 ± 244.959
    Birth weight <10th percentile, n (%)9 (16)6 (11).471
    Intubation at birth, n (%)12 (21)18 (33).148
    Surfactant rescue therapy, n (%)19 (33)15 (27).525
Neonatal period
    Oxygen therapy at 36 wk’ postmenstrual age, n (%)10 (17)10 (18).896
    Cerebral hemorrhage.096
        Grade 1, n (%)11 (19)7 (13)
        Grade 2, n (%)11 (19)8 (15)
        Grade 3, n (%)1 (2)1 (2)
        Grade 4, n (%)5 (9)2 (4)
    Ischemic cerebral damage, all grades, n (%)10 (17)7 (13).502
Development until age 5.5 y
    Neurologic outcome at 2 y.517
        Suspect, n (%)7 (12)7 (13)
        Abnormal, n (%)5 (9)7 (13)
    Mean Mental Development Index at 2 y ± SD*98 ± 22102 ± 25.369
    Mean Psychomotor Development Index at 2 y ± SD (N)*89 ± 20 (57)86 ± 21 (53).423
    Neurologic outcome at 5.5 y.863
        Suspect, n (%)20 (35)21 (38)
        Abnormal, n (%)7 (12)6 (11)
    RAKIT IQ 5.5 y ± SD95 ± 1698 ± 19.316
    CBCL total score at 5.5 y ± SD (N)51 ± 12 (55)50 ± 11 (54).641
  • RAKIT indicates Revised Amsterdam Children’s Intelligence Test.

  • * As assessed by using the Bailey Scales of Infant Development, Dutch version 1983.25

  • A higher score means worse outcome.