Table 3.

Respiratory Data According to Initial Ventilatory Support

EI/MV in the DRSecondary EI/MV (RDS)No EI/MV Attributable to RDS
A 1994A 1996A 1994B 1996A 1994C 1996
n 222210101919
RDS >grade 2, n (%)9 (41)13 (59)6 (60)6 (60)9 (47)2 (11)*
§pH7.32 ± .14 7.28 ± .15 7.28 ± .15 7.21 ± .08 7.33 ± .09  >7.23 ± .08**
§pH <7.2, n (%)3 (14)4 (18)1 (10)4 (40)06 (32)*
§Paco 2 (mm Hg)35 ± 1042 ± 1742 ± 13 >60 ± 14** 39 ± 13 >54 ± 13**
§Paco 2 (kPa)4.7 ± 1.35.6 ± 2.35.6 ± 1.7 >8.0 ± 1.9** 5.2 ± 1.7 >7.2 ± 1.7**
§Hypocapnia, n (%)8 (36)6 (27)2 (20)05 (26)0
§Hypercapnia¶¶, n(%)05 (23)* 1 (10)5 (50)2 (11)5 (26)
§Spo 2 89 ± 8 88 ± 1192 ± 6 86 ± 7 90 ± 8 87 ± 10
§Fio 2 .44 ± .26.57 ± .29.46 ± .26.45 ± .18.45 ± .30.28 ± .09
HFO20 (91)11 (50)** 6 (60)3 (30)16 (84)
Fio 2 .42 ± .27.49 ± .27.44 ± .35.45 ± .18.31 ± .48
Paw (cm H2O)12 ± 2  >11 ± 3*12 ± 3 11 ± 3 12 ± 3 
Ventilator rate (min−1)# 100 (n = 1)69 ± 1583 ± 2467 ± 8 73 ± 10
PIP (cm H2O)# 24 (n = 1)22 ± 4 25 ± 1 19 ± 3 22 ± 6 
Amplitude (HFO)33 ± 1037 ± 1626 ± 1128 ± 8 31 ± 13
Surfactant,n (%)13 (59)19 (86)8 (80)7 (70)12 (63)
Cumulative dose (mg/kg)91 ± 89 >183 ± 122* 122 ± 72 121 ± 104113 ± 105
Number of doses, n 1 (0–4)2 (0–5)2 (0–3)1.5 (0–5)2 (0–5)
  • Abbreviations: HFO, high frequency oscillation (600 min−1); Paw, mean airway pressure; PIP, peak inspiratory pressure.

  • * P < .05;

  • ** P < .01.

  • A total of 5 ELBWI had no RDS but EI/MV attributable to sepsis (n = 1) or apnea (n = 4) at the age of 77 (21–168) h.

  • Numbers are different from the whole groups, only data of pairs matched for gestational age and weight are given.

  • § At time of admission to the NICU.

  • Paco 2 < 30 mm Hg (<4.0 kPa);

  • ¶¶ Paco 2 > 60 mm Hg (>8.0 kPa).

  • Initial ventilator settings.

  • # Intermittent mandatory ventilation.