Table 4.

Effectiveness of Short-term Therapies for UTI Grouped by Duration and Agent

DrugDuration, dSample SizeClinical NotesEfficacy, %95% CI for EfficacyWeighted Average, %Pooled 95% CICommentsReferences
Amoxicillin1 Dose102–17 y7041.6 –98.47041.6 –98.459
Amoxicillin1 Dose102–17 y7041.6 –98.47049.9 –90.159
Amoxicillin1 Dose102–17 y10070.0 –100.08065.7 –94.359
Amoxicillin1 Dose182–18 y7858.9 –97.17967.8 –90.7107
Amoxicillin1 Dose242–12 y, at 4 d after treatment9281.1 –100.08474.9 –92.1Amoxicillin 1 dose108
Amoxicillin 424CRP−5434.1 –73.97667.6 –84.7Amoxicillin 4 d55
Amoxicillin1028CRP−6345.1 –80.97365.4 –81.055
Amoxicillin1032CRP+6953.0 –85.07265.3 –79.355
Amoxicillin10162–17 y7553.8 –96.27365.9 –79.259
Amoxicillin10162–17 y7553.8 –96.27366.4 –79.159
Amoxicillin10162–17 y8872.1 –100.07467.9 –80.059
Amoxicillin10111 mo–14 y8259.3 –100.07468.5 –80.249
Amoxicillin108Cx-at 17 d, 2–18 y8763.7 –100.07569.1 –80.5109
Amoxicillin10152–16 y9380.1 –100.07670.5 –81.4110
Amoxicillin10172–18 y8872.6 –100.07771.6 –82.0111
Amoxicillin10252–12 y, at 4 d after treatment9688.3 –100.07873.7 –83.3108
Amoxicillin10273–16 y5233.2 –70.87671.4 –80.9Amoxicillin 10 d112
Ampicillin10272 mo–12 y6344.8 –81.26344.8 –81.2113
Ampicillin1026Average 5 y8875.5 –100.07563.6 –86.9114
Ampicillin10112 mo–11 y9174.1 –100.07867.8 –88.1115
Augmentin 7260–12 y8064.6 –95.48064.6 –95.4116
Cefodroxil1 Dose362–16 mo5639.8 –72.25639.8 –72.2117
Cefodroxil10632–16 mo8070.1 –89.98070.1 –89.9117
Keflex10153–16 y6035.2 –84.86035.2 –84.8112
Keflex10505 mo–12 y8473.8 –94.27868.5 –88.5118
Nitrofurantoin10261 mo–12 y4223.0 –61.04223.0 –61.0119
Pipemidic acid 5312–14 y8775.2 –98.88775.2 –98.857
Pipemidic acid10312–14 y9485.6 –100.09485.6 –102.457
Pivmecillinam 3781–15 y7767.7 –86.37767.7 –86.356
SMX10391 mo–14 y8269.9 –94.18269.9 –94.149
SMX10505 mo–12 y9284.5 –99.58880.8 –94.5118
Sulfametrizole 3961–15 y8173.2 –88.88173.2 –88.856
Sulfametrizole10901–15 y7464.9 –83.17464.9 –83.156
TMP1 Dose442–16 y7764.6 –89.47764.6 –89.460
TMP-SMX1 Dose1014 mo–11 y7041.6 –98.47041.6 –98.4120
TMP-SMX1 Dose423 mo–12 y9385.3 –100.08979.9 –97.258
TMP-SMX1 Dose393 mo–12 y8066.8 –92.28577.3 –92.1TMP-SMX 1 dose58
TMP-SMX 1236 mo–12 y9586.1 –100.09586.1 –100.0TMP-SMX 161
TMP-SMX 3403 mo–12 y9080.7 –99.39080.7 –99.358
TMP-SMX 3363 mo–12 y9486.9 –100.09286.0 –98.258
TMP-SMX 323Cx-, 3 mo–16 y10087.0 –100.09489.2 –98.6TMP-SMX 3 d121
TMP-SMX 7503 mo–12 y10094.0 –100.0100100.0 –100.058
TMP-SMX 7503 mo–12 y9284.5 –99.59692.2 –99.858
TMP-SMX 7462–16 y9894.0 –100.09793.7 –99.660
TMP-SMX 7196 mo–12 y10084.2 –100.09794.4 –99.661
TMP-SMX 71014 mo–11 y8055.2 –104.89693.2 –98.9TMP-SMX 7 d120
TMP-SMX10536 mo–10 y8777.9 –96.18777.9 –96.1122
TMP-SMX10351 mo–12 y8674.5 –97.58779.5 –93.7119
DrugDuration, dSample SizeClinical NotesEfficacy, %95% CI for EfficacyWeighted Average, %Pooled 95% CICommentsReferences
TMP-SMX1014Cx-at 17 d, 2–18 y10078.6 –100.08882.2 –94.6109
TMP-SMX1020Cx-, 3 mo–16 y10085.0 –100.09085.1 –95.6121
TMP-SMX10192–16 y9585.2 –104.89186.2 –95.7110
TMP-SMX10182 mo–5 y10083.3 –100.09287.8 –96.2123
TMP-SMX10433–16 y9385.4 –100.09288.5 –95.9112
TMP-SMX10292 mo–12 y10089.7 –100.09389.9 –96.4TMP-SMX 10 d113
Various 3316 mo–15 y7458.6 –89.47458.6 –89.4124
Various10316 mo–15 y8065.9 –94.18065.9 –94.1124
Amoxicillin1 Dose102–17 y7041.6 –98.47041.6 –98.459
Amoxicillin1 Dose102–17 y7041.6 –98.47049.9 –90.159
Amoxicillin1 Dose102–17 y10070.0 –100.08065.7 –94.359
Amoxicillin1 Dose182–18 y7858.9 –97.17967.8 –90.7107
Amoxicillin1 Dose242–12 y, at 4 d after treatment9281.1 –100.08474.9 –92.1Amoxicillin 1 dose108
Cefodroxil1 Dose362 mo–16 m5639.8 –72.2117
TMP-SMX1 Dose1014 mo–11 y7041.6 –98.4120
TMP1 Dose442–16 y7764.6 –89.460
TMP-SMX1 Dose423 mo–12 y9385.3 –100.09385.3 –100.758
TMP-SMX1 Dose393 mo–12 y8066.8 –92.28779.1 –93.958
TMP-SMX1236 mo–12 y9586.1 –100.08882.2 –94.5TMP-SMX 1 dose61
Pivmecillinam3781–15 y7767.7 –86.356
Sulfametrizole3961–15 y8173.2 –88.856
TMP-SMX3403 mo–12 y9080.7 –99.39080.7 –99.358
TMP-SMX3363 mo–12 y9486.9 –100.09286.0 –98.258
TMP-SMX323Cx-, 3 mo–16 y10087.0 –100.09489.2 –98.6TMP-SMX 3 d121
Various3316 mo–15 y7458.6 –89.4124
Amoxicillin424CRP−5434.1 –73.95434.1 –73.9Amoxicillin 4 d55
Pipemidic acid5312–14 y8775.2 –98.857
Augmentin7260–12 y8064.6 –95.4116
TMP-SMX7503 mo–12 y10094.0 –100.0100100.0 –100.058
TMP-SMX7503 mo–12 y9284.5 –99.59692.2 –99.858
TMP-SMX7462–16 y9894.0 –100.09793.7 –99.660
TMP-SMX7196 mo–12 y10084.2 –100.09794.4 –99.661
TMP-SMX71014 mo–11 y8055.2 –100.09693.2 –98.9TMP-SMX 7 d120
Amoxicillin1028CRP−6345.1 –80.96345.1 –80.955
Amoxicillin1032CRP+6953.0 –85.06654.2 –78.255
Amoxicillin10162–17 y7553.8 –96.26857.6 –78.559
Amoxicillin10162–17 y7553.8 –96.26959.8 –78.759
Amoxicillin10162–17 y8872.1 –100.07263.6 –80.559
Amoxicillin10111 mo–14 y8259.3 –100.07365.0 –80.949
Amoxicillin108Cx- at 17 d, 2–18 y8763.7 –100.07466.2 –81.5109
Amoxicillin10152–16 y9380.1 –100.07668.8 –82.9110
Amoxicillin10172–18 y8872.6 –100.07770.6 –83.7111
Amoxicillin10252–12 y, at 4 d after treatment9688.3 –100.08073.9 –85.5108
Amoxicillin10273–16 y5233.2 –70.87670.4 –81.9Amoxicillin 10 d112
Ampicillin10272 mo–12 y6344.8 –81.2113
Ampicillin1026Average 5 y8875.5 –100.0114
Ampicillin10112 mo–11 y9174.1 –100.0115
Cefodroxil10632 mo–16 m8070.1 –89.9117
DrugDuration, dSample SizeClinical NotesEfficacy, %95% CI for EfficacyWeighted Average, %Pooled 95% CICommentsReferences
Keflex10153–16 y6035.2 –84.8112
Keflex10505 mo–12 y8473.8 –94.2118
Nitrofurantoin10261 mo–12 y4223.0 –61.0119
Pipemidic acid10312–14 y9485.6 –100.057
SMX10391 mo–14 y8269.9 –94.149
SMX10505 mo–12 y9284.5 –99.5118
Sulfametrizole10901–15 y7464.9 –83.156
TMP-SMX10536 mo–10 y8777.9 –96.18777.9 –96.1122
TMP-SMX10351 mo–12 y8674.5 –97.58779.5 –93.7119
TMP-SMX1014Cx- at 17 d, 2–18 y10078.6 –100.08882.2 –94.6109
TMP-SMX1020Cx-, 3 mo–16 y10085.0 –100.09085.1 –95.6121
TMP-SMX10192–16 y9585.2 –104.89186.2 –95.7110
TMP-SMX10182 mo–5 y10083.3 –100.09287.8 –96.2123
TMP-SMX10433–16 y9385.4 –100.69288.5 –95.9112
TMP-SMX10292 mo–12 y10089.7 –100.09389.9 –96.4TMP-SMX 10 d113
Various10316 mo–15 y8070.3 –94.18070.3 –94.1124