Table 6.

CF Infants: Immunization Response to Trivalent Influenza Vaccine

CF URI-OnlyCF LRI
GMT PreGMT Post≥4-Fold Antibody Rise (n = 16)GMT PreGMT Post≥4-Fold Antibody Rise (n = 12)
Influenza A virus
 H3N23.3  ± 1.55.0  ± 2.36 /16* (38%)2.6  ± 2.23.4  ± 2.42 /12 (17%)
 H1N12.6  ± 2.87.7  ± 2.511 /16 (69%)1.4  ± 1.34.9  ± 2.33 /12 (25%)
Influenza B virus0.7  ± 0.43.2  ± 1.910 /16 (63%)1.0  ± 1.31.3  ± 1.51 /12 (8%)
  • Data are expressed as percentages or as mean ± standard deviation (SD) values.

    Abbreviations: CF URI-only, cystic fibrosis infants who had only upper respiratory tract infections during the respiratory virus season; CF LRI, cystic fibrosis infants who also had at least one lower respiratory tract infection during the respiratory virus season; GMT, geometric mean titer ± standard deviation (SD) expressed at log 2; Pre, before start of respiratory virus season; Post, after respiratory virus season. Note: Change of 2 units is equal to a four-fold antibody rise.

  • * Number of infants with ≥4-fold rise/total number of infants vaccinated.

  • χ2, 1 df, P = .056, compared with CF URI-only.

  • χ2, 1 df, P = .01, compared with CF URI-only.