Table 1.

Characteristics of Patients at Randomization

CharacteristicEarly-treated Group (n = 33)Late-treated Group (n = 27)P
Median (Range)
Birth weight (g)950  (665–1600)935  (618–1555).84
Gestational age (wk)27  (25–29)28  (25–29).54
Age at randomization (h)4.1  (0.3–40.1)*4.5  (1.7–41.3)*.55
a/APo2 at randomization0.28  (0.22–0.38)*0.28  (0.08–0.77)*.69
TcPco2 (mm Hg) at randomization50  (34–103)47  (30–74).69
Number (%)
Male sex17  (52)18  (67).24
Born in treating hospital30  (91)24  (89).20
Cesarean section25  (76)17  (63).28
Theophylline21  (64)18  (67).81
Antenatal steroid26  (79)22  (81).80
 Two doses20  (61)17  (63).85
  • * In both treatment groups the lowest age at entry was 2.0 hours and the range of a/APo2 was 0.22 to 0.35 for infants fulfilling the entry criteria strictly (n = 54). One infant in each treatment group was randomized before 2 hours; the late-treated also had a/APo2 <0.22. One infant treated early and 3 infants treated late had a/APo2 >0.35.