The Newer Antidepressant Drugs Examined by the FDA

Drug/ManufacturerInitial FDA Adult Use Approval DatesFDA Pediatric Approval DatesCurrent Approval Status
Prozac (fluoxetine)/Eli Lilly19872003Approved for adult MDD, OCD, bulimia, and PD
Approved for pediatric MDD and OCD
Zoloft (sertraline)/Pfizer19911997Approved for use in adults with MDD, OCD, PD, PTSD, PMDD, and SAD
Approved for pediatric OCD
Paxil (paroxetine)/GlaxoSmithKline1992Approved for use in adults with MDD, OCD, PD, SAD, GAD, and PTSD
Not recommended for use in pediatric populations
Luvox (fluvoxamine)/Solvay19941997Solvay Pharmaceuticals, Inc, voluntarily requested discontinued use as antidepressant in the United States in 2002 for commercial reasons
Celexa (citalopram)/Forest1998Approved for use in adult MDD
Wellbutrin (bupropion)/GlaxoSmithKline1985Approved for use in adult MDD
Effexor (venlafaxine)/Wyeth1993Approved for adult MDD, GAD, and SAD
Wyeth-Ayerst voluntarily labeled as not recommended for use in pediatric patients in 2003
Serzone (nefazodone)/Bristol-Myers Squibb1994Bristol-Myers Squibb voluntarily discontinued sales in 2004 in the United States for commercial reasons
Remeron (mirtazapine)/Organon1996Approved for adult MDD
  • OCD indicates obsessive compulsive disorder; PD, panic disorder; PTSD, posttraumatic stress disorder; PMDD, premenstrual dysphoric disorder; SAD, social anxiety disorder; GAD, generalized anxiety disorder.