Table 1.

Univariate Comparisons of Variables (Mean [SD]) Associated With Outcomes

VariablesBlindness Attributable to ROPNeurodevelopmental Impairment
Blind
(n = 15)
Nonblind
(n = 113)
OR (CI)
per Unit
PImpaired
(n = 21)
Nonimpaired
(n = 107)
OR (CI)P
Gestational age (wk)23.9 (1.0)24.6 (1.1)0.548 (0.309–0.972).04024.5 (1.3)24.5 (1.1)1.028 (0.674–1.570).899
pH at 48 hours old (0.1 unit)7.32 (0.13)7.34 (0.09)0.733 (0.366–1.466).3807.31 (0.09)7.34 (0.07)0.531 (0.282–1.000).050
Base deficit at 48 hours old
(mmol/L)
−5.3 (4.1)−5.2 (3.1)1.015 (0.859–1.200).8606.4 (3.0)5.0 (3.2)1.148 (0.995–1.324).059
Duration phototherapy
(per 10 hours)
109 (46)83 (48)1.107 (0.996–1.232).06091 (39)85 (50)1.025 (0.932–1.127).610
Blood glucose variable*4.9 (2.8)3.7 (2.4)0.166 (0.762–47.665).0893.9 (1.7)3.9 (2.6)2.560 (0.704–9.304).154
pH variable**4.7 (6.5)3.7 (3.0)1.062 (0.936–1.203).3505.2 (2.8)3.6 (3.6)1.112 (0.989–1.250).075
Intraventricular hemorrhage (%)
5 (33)17 (15)2.824 (0.858–9.290).0789 (43)13 (12)5.423 (1.915–15.356).001
 (dichotomous variable) (n = 22)
  • * Minimal blood glucose concentration ≥2.2 mmol/L (40 mg/dL) during the first 48 hours after birth.

  • ** The number of pH measurements <7.25 during the period that the serum bilirubin concentration exceeded 5.8 mg/dL (100 μmol/L).

    The left side of the table compares blind with nonblind infants, and the right side compares severely neurodevelopmentally impaired infants with those who were not severely impaired. Only those variables having a P value <.10 for at least one of the two outcomes are included in the Table. For continuous variables, odds ratios andP values are based on univariate logistic regression analyses.