TABLE 2.

Disease-Related and Vaccination Program–Related Cost Assumptions

Cost of DiseaseBase CaseRangeDistributionSource
Costs related to the acute event
    Medical care, acute meningococcal disease$28 489$14 244–$42 733TriangRef 2; 50% on either side
    Parents' lost time from work$1710NANARef 34
    Public health response$4317$1204–$11 222Lognorm, truncAppendix 3
Lifetime costs
    Medical care, skin scarring$5698$2849–$8547TriangRef 2; 50% on either side
    Medical care, single amputation$166 317$83 158–$249 475Triang
    Medical care, multiple amputations$199 580$99 790–$299 369Triang
    Medical care, hearing loss$68 640$26 190–$68 640NARefs 39 and 62
    Residential care, neurologic disability$2 503 677$923 013–$3 288 152Lognorm, truncRef 40
    Special education, neurologic disability (0–9 y of age)$204 014$148 642–$272 583TriangRef 41
    Special education, neurologic disability (10–17 y of age)$138 545$100 943–$185 110TriangRef 41
    Cost per dose of vaccine (public sector)$63.51$51–$95TriangRefs 44, 63, and 64
    Cost per dose of vaccine (private sector)$76.74$61–$98TriangRefs 44 and 63
    Proportion of vaccine purchased in the public sector53.75%43.75–63.75%TriangRef 45; 10% on either side
    Proportion of vaccine received in public health clinics22.00%12–32%NARef 45; 10% on either side
    Cost of vaccine administration in public health clinics$5.00$5–$15NARef 45
    Cost of vaccine administration in private-sector clinics$15.09$5–$20TriangRef 45
Adverse events
    Rate of moderate adverse events0.0003NANARef 46
    Rate of serious adverse events0.000002NANARef 46
    Cost per moderate adverse event$115.91NANARef 47
    Cost per serious adverse event (before applying cost/charge ratio)$16 245.00NANARef 45
  • Triang indicates triangular; trunc, truncated; lognorm, log normal; nml, normal; NA, not applicable.