TABLE 2.

Laboratory Features and Potential Risk Factors of Delayed Diagnosis in KS

CharacteristicEDGDDGP Value
Days of fever, mean (95% CI)*6.1 (5.6–6.7)13.0 (12.0–14.0)<.005
Days of rash, mean (95% CI)*4.1 (3.4–4.7)10.1 (8.9–11.4)<.005
Days of red eyes, mean (95% CI)5.2 (4.1–6.2)7.0 (5.2–8.9).005
Days of oral changes, mean (95% CI)2.7 (2.0–3.8)6.3 (4.8–7.8).02
Days of extremity changes, mean (95% CI)1.5 (0.8–2.1)3.8 (2.7–4.9).001
Presence of adenopathy, %39.312.0.01
CRP, mg/dL, mean (95% CI)12.5 (10.5–14.7)5.7 (1.97–9.4).002
Platelet count >450 000/mm3, %*30.056.0.018
ESR, mm/h65.4 (59.4–71.4)56.7 (45.8–67.5)NS
Age, y, mean (95% CI)2.9 (2.3–3.4)3.3 (2.5–4.5)NS
Residence in metropolitan Denver, %64.569.0NS
Type of primary care provider, % pediatricians8375NS
No. of antibiotic prescriptions, mean (95% CI)1.7 (1.5–2.0)2.1 (1.6–2.6)NS
First contact with medical provider, day of illness, mean (95% CI)2.7 (2.3–3.0)2.5 (1.8–3.1)NS
Number of medical providers seen before diagnosis, mean (95% CI)3.11 (2.9–3.3)3.4 (3.0–3.8)NS
  • * In a stepwise linear-regression model, using log10 days of illness prior to diagnosis as the dependant variable, the significant predicting variables to diagnosis were days of fever, days of rash, and platelet count (R2 = 0.75; P < .001).