TABLE 2.

Outcomes for Pain, Antibody Response, and Local Skin Reactions After Exposure to Amethocaine and Placebo

OutcomePlacebo GroupAmethocaine GroupP Value
Pain (mean MBPS scores; SD)(n = 59)(n = 61)
    Baseline (total score)3.0 (2.0)3.3 (2.1).399
    Postinjection (total score)5.3 (2.5)4.8 (2.6).309
    Difference2.3 (2.2)1.5 (1.6).029*
Postvaccination antibody response(n = 90)(n = 90)
    Combined measles, mumps, and rubella immunity
        Immune, %79 (88)78 (87).823
    Geometric mean, SD
        Measles, AU55.0 (35.8)53.2 (43.9).863
        Mumps, AU163.3 (55.0)119.3 (74.9).012*
        Rubella, IU/mL140.4 (65.0)107.8 (84.0).098
Local skin reactions(n = 59)(n = 61)
    Redness2652<.001*
    Pallor1629.018*
    Edema427<.001*
  • T test and χ2 analysis were performed.

  • * Statistically significant at the P = .05 level.

  • Overall immunity determined by combining individual antibody types for each participant.