TABLE 3.

Recommendations for Prophylaxis

Recommended ManeuverOrganizations RecommendingOrganizations Recommending AgainstEvidence From TrialsReferences to Reviews and TrialsResults
Folate supplementation for women of childbearing ageAAP, CTF, USPSTF, AAFPYes854 trials showed substantial decrease in neural tube defects with supplementation
Iron supplementationAAP, ICSI, USPSTF, CTF (iron-rich foods)USPSTF (iron supplements)Yes8691, 96, 144147Trials showed decreased prevalence of iron deficiency, developmental outcomes did not change, no data on long-term outcome, no increase in infectious illnesses with supplementation
Oral fluoride treatmentUSPSTF, CTF, ICSI, AAFPNo97, 148
Newborn ocular prophylaxisUSPSTF, CTF, AAFPNo98101Trials compared agents but no trials compared prophylaxis with placebo or no prophylaxis