TABLE 5.

Results of Univariate and Multivariate Analyses of Prenatal and Postnatal Risk Factors Associated With Serious Neuromorbidity and Specific NICU-Related Complications as Separate Outcomes (Defined in Text) in the 175 Surviving EPT Infants

Independent Risk Factor (All Yes/No Unless Stated)Outcome Serious NeuromorbidityOutcome NICU-Specific Complications
Univariate AnalysisMultivariate AnalysisUnivariate AnalysisMultivariate Analysis
OR (95% CI)POR (95% CI)POR (95% CI)POR (95% CI)P
Intrauterine transfer0.99 (0.48–2.02).980.78 (0.34–1.80).566
Medically assisted conception1.95 (0.66–5.74).222.98 (0.75–11.13).122
PROM (>24 h)0.46 (0.18–1.14).090.83 (0.30–2.30).731
CS vs vaginal delivery0.56 (0.25–1.28).170.42 (0.17–1.06).067
Male gender1.08 (0.52–2.22).831.22 (0.53–2.80).636
Gestation (per wk)0.91 (0.61–1.35).660.97 (0.61–1.53).905
BW (per 100 g)1.00 (0.99–1.00).240.99 (0.99–1.00).050
Multiple0.63 (0.27–1.47).290.53 (0.20–1.40).201
Air leak syndrome1.20 (0.46–3.11).705.32 (1.06–26.71).042
Endotracheal ventilation0.67 (0.14–3.14).611.68 (0.39–7.23).485
Days on the ventilator1.03 (1.00–1.05).011.03 (1.01–1.05).0021.07 (1.02–1.13).0071.07 (1.02–1.12).002
Surfactant therapy1.76 (0.61–5.05).280.66 (0.21–2.07).481
Minimal Fio2 <12 h2.43 (0.73–8.05).142.32 (0.56–9.62).244
Maximal Fio2 <12 h0.53 (0.24–1.16).110.32 (0.13–0.76).0100.37 (0.17–0.79).011
  • PROM indicates premature rupture of membranes.