Table 4.

Problems and Variation in the Selection and Specification of Patients in Outpatient Trials

First Author of Trial
Schuh13Klassen14Schweich15Gadomski18Gadomski19
Selection of Patients
 Explicit criteria for diagnosis
 of bronchiolitis
000++
 Baseline chest radiograph done 0*0+0+
 Patients already on bronchodilators
 excluded
0+++0
 Patients with asthma excluded+++++
 Only patients with RSV enrolled00000
Specification of Patients
 Assessed prestudy duration of illness+0++0
 Full evaluation of important baseline
 patient attributes
++++0
 Age in months: mean of treatment and
6.1, 5.37.3, 7.06.0, 8.75.6, 5.84.0, 5.0
  placebo groups (overall range)(1.5–24)(<24)(0–24)(0–15)(<18)
 Specified proportion of patients
 <6 months old
+++00
 Viral etiology testingRSV, influenza A,
parainfluenza 3
RSVRSVRSV, parainfluenza,
cytomegalovirus,
adenovirus
RSV, influenza,
parainfluenza,
adenovirus
  • * Chest radiograph done at discharge.

  • Range not provided.

  • Expressed as median age.