Appendix C.

Cost Variables Used in Decision Analysis Model (Estimate and 95% CI)

EstimateLower LimitHigher LimitData Source
Period 1
    iNO pathway$11 165.51$9976.68$12 397.54Cohort
    CV pathway$8247.076025.3010 868.49Cohort
Period 2
    One-time ECMO procedure costs$2500.00$0$5000.00Cohort
    iNO pathway
        Survival with major side effects with ECMO$38 326.79$27 373.92$50 564.12Cohort
        Survival with minor side effects with ECMO$20 404.99$14 842.52$27 645.53Cohort
        Survival with no side effects with ECMO$18 850.08$14 347.56$24 275.02Cohort
        Survival with major side effects without ECMO$14 709.22$10427.00$20 037.33Cohort
        Survival with minor side effects without ECMO$11 682.62$8122.85$16 716.32Cohort
        Survival with no side effects without ECMO$8404.46$5922.66$11 030.34Cohort
        Death with major side effects with ECMO$45 371.42$30 000.00$50 000.00Cohort
        Death with minor side effects with ECMO$0$0$0Cohort
        Death with no side effects with ECMO$0$0$0Cohort
        Death with major side effects without ECMO$1372.58$0$5490.32Cohort
        Death with minor side effects without ECMO$000Cohort
        Death with no side effects without ECMO$000Cohort
    CV pathway
        Survival with major side effects with ECMO$34 310.18$20 236.96$49 753.73Cohort
        Survival with minor side effects with ECMO$24 701.58$15 778.93$35 340.21Cohort
        Survival with no side effects with ECMO$15 209.52$13 270.15$17 635.77Cohort
        Survival with major side effects without ECMO$5247.360$15 059.54Cohort
        Survival with minor side effects without ECMO$000Cohort
        Survival with no side effects without ECMO$3147.19$619.05$9183.66Cohort
        Death with major side effects with ECMO$000Cohort
        Death with minor side effects with ECMO$000Cohort
        Death with no side effects with ECMO$000Cohort
        Death with major side effects without ECMO$000Cohort
        Death with minor side effects without ECMO$000Cohort
        Death with no side effects without ECMO$000Cohort
Period 3
    iNO pathway
        Discharged without need for medical support with major side effects with ECMO$22 133.71$15 574.69$30 024.44Cohort
        Discharged with need for medical support with major side effects with ECMO$22 970.09$15 963.6830 004.24Cohort
        Discharged without need for medical support with minor side effects with ECMO$13 661.34$9778.45$18 260.49Cohort
        Discharged with need for medical support with minor side effects with ECMO$16 867.77$14 083.06$20 658.36Cohort
        Discharged without need for medical support with no side effects with ECMO$14 707.22$9633.23$19 176.51Cohort
        Discharged with need for medical support with no side effects with ECMO$7616.02$5000.00$12 000.00Cohort
        Discharged without need for medical support without major side effects without ECMO$10 717.31$7065.56$16 176.53Cohort
        Discharged with need for medical support without major side effects without ECMO$18 268.99$14 062.21$24 701.57Cohort
        Discharged without need for medical support without minor side effects without ECMO$9999.62$7824.17$12 195.43Cohort
        Discharged with need for medical support without minor side effects without ECMO$15 846.71$12 000.00$20 000.00Cohort
        Discharged without need for medical support without no side effects without ECMO$8913.77$7711.24$10 161.68Cohort
        Discharged with need for medical support without no side effects without ECMO$15 770.17$12 000.00$20 000.00Cohort
    CV pathway
        Discharged without need for medical support with major side effects with ECMO$18 293.47$15 536.09$22 348.06Cohort
        Discharged with need for medical support with major side effects with ECMO$23 552.71$11 899.61$38 321.32Cohort
        Discharged without need for medical support with minor side effects with ECMO$9626.54$7000.00$20 000.00Cohort
        Discharged with need for medical support with minor side effects with ECMO$23 767.99$13 392.89$42 852.11Cohort
        Discharged without need for medical support with no side effects with ECMO$12 446.82$8478.62$14 631.28Cohort
        Discharged with need for medical support with no side effects with ECMO$18 244.11$15 847.82$21 868.26Cohort
        Discharged without need for medical support without major side effects without ECMO$0$0$0Cohort
        Discharged with need for medical support without major side effects without ECMO$16 855.77$8245.26$22 772.98Cohort
        Discharged without need for medical support without minor side effects without ECMO$000Cohort
        Discharged with need for medical support without minor side effects without ECMO$000Cohort
        Discharged without need for medical support without no side effects without ECMO$10 208.61$7210.12$13 783.32Cohort
        Discharged with need for medical support without no side effects without ECMO$0$0$0Cohort