Appendix A.

Outcome Probabilities Used in Decision Analysis Model (Estimate and 95% CI)

EstimateLower LimitHigher LimitData Source
iNO pathway
    Need for ECMO rescue0.30620.26230.3529refs 1218 meta-analyses
    Side effects on ECMO0.78950.63410.9167Cohort
    Chance of major side effects with ECMO0.69570.50.8621Cohort
    Survival with major side effects on ECMO0.94440.81Cohort
    Survival without need for home medical support with major side effects on ECMO0.250.05880.4706Cohort
    Survival without need for home medical support with minor side effects on ECMO0.6250.251Cohort
    Survival without need for home medical support with no side effects on ECMO0.85710.44441Cohort
    Side effects without ECMO0.62120.49180.7544Cohort
    Chance of major side effects without ECMO0.66670.51280.8125Cohort
    Survival with major side effects without ECMO0.83330.65220.96Cohort
    Survival with minor side effects without ECMO0.90910.66671Cohort
    Survival without need for home medical support with major side effects without ECMO0.36360.15380.6Cohort
    Survival without need for home medical support with minor side effects without ECMO0.90.66671Cohort
    Survival without need for home medical support with no side effects without ECMO0.94740.81251Cohort
Conventional treatment pathway
    Need for ECMO rescue0.53710.48220.5913refs 1218 meta-analyses
    Side effects on ECMO0.70590.50.8889Cohort
    Chance of major side effects with ECMO0.57140.30770.8333Cohort
    Survival with Major side effects with ECMO0.94440.81Cohort
    Survival without need for home medical support with major side effects with ECMO0.222200.6Cohort
    Survival without need for home medical support with minor side effects with ECMO0.166700.6667Cohort
    Side effects without ECMO0.60.30.8667Cohort
    Chance of major side effects with ECMO111Cohort
    Survival with major side effects without ECMO0.66670.21Cohort
    Survival without need for home medical support with major side effects without ECMO000Cohort
    Survival without need for home medical support with no side effects without ECMO111Cohort
Utility variables
    Survival without need for home medical support (QALY)111Set by study
    Survival with need for home medical support (QALY)0.870.50.99ref 25
    Death (QALY)000Set by study