Radioactive Compounds That May Require Temporary Cessation of Breastfeeding: Recommendations of the International Commission on Radiologic Protection

CompoundExamplesExample of ProceduresRecommended Time for Cessation of BreastfeedingComments
14C-labeledTriolein, glycocholic acid, ureaHelicobacter pylori breath testNoneNo approved US products
99mTc-labeledDMSA, DTPA, phosphonates (MDP), PYP, tetrofosminMultiple: imaging of kidney, bone, lung, heart, tumors0 to 4 h, as long as no free pertechnetateConsider discarding at least 1 meal after procedure
Microspheres, pertechnetate, WBC12–24 hRange depends on dose
Sulfur-colloids, RBC in vivo6 h
I-labeled123I, 125I or 131I-iodo hippurateThyroid imaging12 hNote: whole-body irradiation with 131I requires prolonged cessation
Others11C- 11N or 11O-labeledPET scansNoneShort physical half-life
57Co-labeled vitamin B12Schilling test24 hPomeroy 2005119
18F-FDGPET scansNone, first feeding should be expressed breast milk to avoid direct contact120Use alternatives for 10 half-lives (10×109 min= 18 h)a
51Cr-EDTARenal imagingNone
81mKr-gasPulmonary imagingNoneNo approved US products
82Rb chloridePET scan of myocardiumMay resume 1 h after last infusionHalf-life 75 sa
111In-octreotideSPECT, neuroendocrine tumorsNone
111In -WBC1 wkDepends on dose
133XeCardiac, pulmonary, and cerebral imagingNoneHalf-life 5 da
  • DMSA, dimercaptosuccinic acid; DTPA, diethylenetriaminepentaacetate; EDTA, ethylenediaminetetraacetic acid; FDG, fludeoxyglucose; PET, positron emission tomography; PYP, pyrophosphate; RBC, red blood cell; SPECT, single-photon emission computed tomography; WBC, white blood cell.

  • a FDA-approved drug labeling.