TABLE 11.

Major Toxicities of Selected Antiretroviral Drugs for Use as Prophylaxis After Exposure to HIV in Children or Adolescents121

Drug Generic Name (Abbreviation), Trade NameMajor Adverse Effects
Zidovudine (ZDV), RetrovirAnemia, neutropenia, nausea, headache, insomnia, muscle pain, weakness, lactic acidosis, hepatic steatosis
Didanosine (ddI), VidexPancreatitis, neuropathy, diarrhea, abdominal pain, nausea, lactic acidosis, hepatic steatosis
Stavudine (d4T), ZeritPeripheral neuropathy, headache, diarrhea, nausea, insomnia, anorexia, pancreatitis, hepatitis, anemia, neutropenia, lactic acidosis, hepatic steatosis
Lamivudine (3TC), EpivirAbdominal pain, nausea, diarrhea, rash, pancreatitis, lactic acidosis, hepatic steatosis
Ritonavir (RTV), NorvirAbdominal pain, nausea, diarrhea, circumoral paresthesias, taste alteration, increased cholesterol and triglyceride concentrations
Indinavir sulfate (IDV), CrixivanNephrolithiasis, hyperbilirubinemia, nausea, abdominal pain, increased cholesterol and triglyceride concentrations
Nelfinavir mesylate (NFV), ViraceptDiarrhea, nausea, abdominal pain, weakness, rash, increased cholesterol and triglyceride concentrations
Lopinavir/ritonavir (LPV/r), KaletraAbdominal pain, nausea, diarrhea, circumoral paresthesias, taste alteration, increased cholesterol and triglyceride concentrations