TABLE 1.

Baseline Results in 42 Children and Adolescents (18 Girls) With Moderate to Severe OI

AllOI 1OI 3OI 4OI 5P
n4299155
Age (y)11.4 ± 2.69.9 ± 2.411.2 ± 2.711.8 ± 2.412.3 ± 2.9.26
Height (z age)−5.5 ± 3.6−2.2 ± 1.4*−10.3 ± 2.4−5.1 ± 2.7−3.8 ± 2.7*<.001
Weight (z age)−2.5 ± 2.1−1.1 ± 1.8−3.5 ± 1.8−2.4 ± 2.0−1.8 ± 2.3.10
aBMD (z age)−5.2 ± 1.3−4.1 ± 0.8−5.9 ± 1.0−5.2 ± 1.2−5.4 ± 1.6.02
Grip force (z age)−2.7 ± 2.1−0.9 ± 1.1*−4.6 ± 1.9−2.2 ± 1.7−2.8 ± 1.7*<.001
Grip force (z weight)−0.1 ± 1.80.4 ± 1.6−1.0 ± 2.60.4 ± 1.4−0.8 ± 1.6.20
  • Results are also given for OI types 1, 3, 4 and 5. The other diagnostic categories (OI type 6, Cole-Carpenter syndrome, osteoporosis-pseudoglioma syndrome) were too rare for statistical analysis.

    Values are mean ± standard deviation.

    The P value indicates the significance of the difference between OI types 1, 3, 4, and 5 (analysis of variance).

    Significant differences of the 2-score mean value from 0 are indicated by symbols.

  • * P < .05.

  • P < .005.

  • P < .0005.