TABLE 4.

Clinical Characteristics, Bone Ultrasound Measurements, and Collagen Biochemistry in Children With Generalized Joint Hypermobility Without Musculoskeletal Complaints and Reference Group

Generalized Joint Hypermobility Without Musculoskeletal Complaints (n = 16)Reference Group (n = 79)Mean Difference (95% CI)Mean Adjusted Difference (95% CI)*
Clinical characteristics
 Age (y)8.9 (0.2)9.3 (0.7)−0.4 (−0.8, −0.06)
 Body height (cm)1.36 (0.02)1.39 (0.1)−0.03 (−0.07, 0.02)
 Body weight (kg)29.2 (1.1)32.5 (6.0)−3.4 (−6.5, −0.2)
 Quetelet index (kg/m2)15.6 (0.3)16.5 (1.6)−1.0 (−1.9, −0.2)
 Total range of joint motion (degrees)1629.4 (11.1)1542.5 (48.3)86.8 (60.9, 112.8)72.5 (45.1, 99.8)
 Systolic blood pressure (mm Hg)106.7 (2.6)110.8 (9.4)−4.1 (−9.3, 1.1)−1.9 (−7.0, 3.3)
 Diastolic blood pressure (mm Hg)70.1 (1.7)71.9 (6.8)−1.8 (−5.5, 1.9)−0.6 (−4.3, .1)
 Pulse pressure (mm Hg)36.6 (1.6)38.9 (7.0)−2.3 (−6.1, 1.5)−1.2 (−5.3, 2.8)
 Total muscle strength (N)783.2 (32.3)858.4 (127.7)−75.2 (−148.3, −2.0)−22.7 (−75.4, 30.0)
 Total skin extensibility (mm)37.7 (0.6)35.5 (2.8)2.2 (0.6, 3.7)2.4 (0.9, 3.8)
Quantitative bone ultrasound measurements
 BUA (dB/MHz)57.9 (3.6)57.6 (14.4)0.2 (−7.7, 8.2)2.6 (−5.8, 11.1)
 SOS (m/s)1575.6 (7.1)1569.8 (23.2)5.8 (−7.6, 19.2)2.0 (−12.2, 16.3)
Collagen biochemistry
 Hyp/creatinine (μmol/mmol)106.1 (6.3)113.3 (26.7)−7.1 (−21.6, 7.3)−7.5 (−22.7, 7.8)
 HP/creatinine (μmol/mmol)250.3 (19.0)250.9 (69.2)−0.6 (−38.9, 37.7)−2.4 (−42.9, 38.1)
 LP/creatinine (μmol/mmol)75.3 (6.8)74.8 (32.2)0.5 (−16.7, 17.6)−2.3 (−20.8, 16.1)
 Ratio HP/LP3.5 (0.2)3.6 (0.8)−0.1 (−0.5, 0.3)−0.01 (−0.4, 0.5)
  • Values are means (standard error of the mean), unless otherwise indicated.

  • * Adjustment for age, gender, body height, and body weight. Statistically significant associations were considered reached when 95% CIs did not include the null value and are given in boldface