TABLE 3.

Clinical Characteristics, Bone Ultrasound Measurements, and Collagen Biochemistry in Children With Generalized Joint Hypermobility With and Without Musculoskeletal Complaints

Generalized Joint Hypermobility With Musculoskeletal Complaints (n = 15)Generalized Joint Hypermobility Without Musculoskeletal Complaints (n = 16)Mean Difference (95% CI)Mean Adjusted Difference (95% CI)*
Clinical characteristics
 Age (y)8.1 (0.6)8.9 (0.2)−0.8 (−2.1, 0.4)
 Body height (cm)1.30 (0.04)1.36 (0.02)−0.02 (−0.1, 0.1)
 Body weight (kg)30.3 (2.7)29.2 (1.1)1.2 (−4.7, 7.0)
 Quetelet index (kg/m2)16.4 (0.5)15.6 (0.3)0.8 (−0.4, 2.0)
 Total range of joint motion (degrees)1743.2 (12.3)1629.4 (11.1)114.8, (80.9, 148.8)117.8 (77.7, 158.0)
 Systolic blood pressure (mm Hg)100.2 (2.4)106.7 (2.6)−6.5 (−13.9, 1.0)−6.0 (−13.6, 1.6)
(P = .09)
 Diastolic blood pressure (mm Hg)64.3 (1.7)70.1 (1.7)−5.7 (−10.7, −0.7)−4.9 (−10.7, 0.9)
(P = .09)
 Pulse pressure (mm Hg)35.9 (2.0)36.6 (1.6)−0.8 (−6.0, 4.5)−1.0 (−5.9, 3.8)
 Total muscle strength (N)782.2 (62.2)783.2 (32.3)−1.0 (−142.3, 140.2)1.5 (−81.5, 84.5)
 Total skin extensibility (mm)41.5 (0.3)37.7 (0.6)3.8 (2.2, 5.3)3.5 (1.6, 5.3)
Quantitative bone ultrasound measurements
 BUA (dB/MHz)50.4 (2.7)57.9 (3.6)−7.4 (−16.9, 2.1)−9.9 (−20.4, 0.5)
(P = .06)
 SOS (m/s)1544.6 (5.1)1575.6 (7.1)−31.0 (−49.5, −12.5)−27.9 (−48.4, −7.5)
Collagen biochemistry
 Hyp/creatinine (μmol/mmol)123.1 (8.7)106.1 (6.3)17.0 (−4.8, 38.8)21.2 (2.3, 40.1)
 HP/creatinine (μmol/mmol)214.50 (17.5)250.3 (19.0)−35.8 (89.9, 18.3)−35.4 (−101.1, 30.2)
 LP/creatinine (μmol/mmol)59.1 (5.9)75.3 (6.8)−16.2 (−34.7, 2.4)−16.8 (−39.0, 5.4)
(P = .08)
 Ratio HP/LP3.7 (0.2)3.5 (0.2)0.2 (−0.2, 0.7)0.3 (−0.2, 0.8)
  • Values are means (standard error of the mean), unless otherwise indicated.

  • * Adjustment for age, gender, body height, and body weight. Statistically significant associations were considered reached when 95% CIs did not include the null value and are given in boldface.