TABLE 2.

Clinical Characteristics, Bone Ultrasound Measurements, and Collagen Biochemistry in Children With Generalized Joint Hypermobility and Musculoskeletal Complaints and the Total Reference Group

Generalized Joint Hypermobility With Musculoskeletal Complaints (n = 15)Total Reference Group (n = 95)Mean Difference (95% CI)Mean Adjusted Difference (95% CI)*Mean Adjusted Difference (95% CI)
Clinical characteristics
 Age (y)8.1 (0.6)9.2 (0.1)−1.2 (−1.8, −0.5)
 Body height (m)1.3 (0.04)1.4 (0.01)−0.5 (−0.1, 0.01)
 Body weight (kg)30.3 (2.7)31.9 (0.6)−1.6 (−5.3, 2.0)
 Quetelet index (kg/m2)16.4 (0.5)16.5 (0.2)−0.1 (−1.0, 0.8)
 Total range of joint motion (degrees)1743.2 (12.3)1557.2 (5.9)186.1 (154.1, 218.0)177.0 (145.1, 208.9)181.6 (147.7, 215.6)
 Systolic blood pressure (mm Hg)100.2 (2.4)110.1 (1.0)−9.9 (−15.5, −4.3)−8.0 (−13.3, −2.8)−8.0 (−13.4, −2.6)
 Diastolic blood pressure (mm Hg)64.3 (1.7)71.6 (0.7)−7.2 (−11.2, −3.3)−6.0 (−10.0, −2.2)−5.5 (−9.5, −1.4)
 Pulse pressure (mm Hg)35.9 (2.0)38.6 (0.7)−2.7 (−6.8, 1.4)−1.9 (−6.0, 2.1)−2.5 (−6.8, 1.7)
 Total muscle strength (N)782.2 (62.2)846.8 (13.5)−64.7 (−149.0, 19.7)3.2 (−50.8, 57.3)10.1 (−44.9, 65.1)
 Total skin extensibility (mm)41.5 (0.3)35.9 (0.3)5.6 (4.0, 7.2)5.6 (4.0, 7.1)5.5 (3.9, 7.1)
Quantitative bone ultrasound measurements
 BUA (dB/MHz)50.5 (2.7)57.7 (1.5)−7.2 (−15.3, 0.9)−7.2 (−15.4, 1.4)−7.3 (−16.1, 1.4)
 SOS (m/s)1544.6 (5.1)1570.7 (2.5)−26.1 (−39.8, −12.4)−26.8 (−41.1, −12.6)−26.4 (−40.9, −11.8)
Collagen biochemistry
 Hyp/creatinine (μmol/mmol)123.1 (8.7)112.1 (2.7)11.1 (−4.1, 26.3)3.9 (−11.8, 19.5)
 HP/creatinine (μmol/mmol)214.5 (17.5)250.8 (7.2)−42.7 (−82.2, −3.3)−51.3 (−92.2, −10.4)
 LP/creatinine (μmol/mmol)59.1 (5.9)74.9 (3.2)−16.7 (−33.9, 0.5)−18.7 (−36.9,−0.5)
 Ratio HP/LP3.7 (0.2)3.6 (0.1)−0.09 (−0.3, 0.5)0.1 (−0.3, 0.6)
  • Values are means (standard error of the mean), unless otherwise indicated. Statistically significant associations were considered reached when 95% CIs did not include the null value and are given in boldface.

  • * Adjustment for age, gender, body height, and body weight.

  • Adjustment for age, gender, body height and weight, and HP/creatinine.