TABLE 1.

Risks of Death and Complications From Smallpox Immunization (per Million Vaccine Recipients)*

ComplicationAge (Years) at Immunization
11–45–1920+
Death (from all complications)50.50.5Unknown
Progessive vaccinia (vaccinia gangrenosa)10.517
Encephalitis622.54
Eczema vaccinatum14443530
Accidental inoculation507577371606
Generalized rash including hypersensitivity reactions394233140212
  • * Sources: J. M. Neff, MD (personal communication, April 2002), and Lane and Millar.12