TABLE 1.

Characteristics of the Preterm Infants With RDS (n = 29) and Without RDS (n = 12)

CharacteristicsWith RDSWithout RDS
Prenatal factors
 Glucorticoid therapy* (n [%])29 (100)8 (67)
 Preeclampsia (n [%])12 (41)5 (42)
 Clinical chorioamnionitis (n [%])13 (45)0 (0)
 Preterm rupture of membranes
 >24 h antepartum (n [%])8 (24)0 (0)
Delivery
 Vaginal8 (28)6 (50)
 Cesarean section21 (72)6 (50)
Postnatal factors
 Gender (n [%])
  Female14 (48)7 (58)
  Male15 (52)5 (42)
 Gestational age (wk; mean [SD])27.8 (1.8)33.3 (2.2)
 Birth weight (g; mean [SD])979 (263)2125 (385)
 Apgar score (mean [SD])
  1 min6 (2)9 (1)
  5 min7 (1)9 (1)
Cord artery pH (mean [SD])7.2 (0.1)7.3 (0.1)
Surfactant treatment (n [%])26 (90)0 (0)
Clinical neonatal infection§ (n [%])11 (38)0 (0)
Bronchopulmonary dysplasia (n [%])16 (55)0 (0)
  • * Betamethasone, given as 2 doses of 12 mg with a 12-hour interval 1 to 13 days before delivery to enhance fetal lung maturation.

  • Diagnosed by typical clinical picture, blood leukocyte count >14 × 109/L, and serum C-reactive protein concentration >50 mg/L.

  • Patients receiving Curosurf, a natural surfactant preparation of porcine lung; each dose was 100 mg/kg.

  • § Infection as defined by presence of risk factor(s) for infection (chorioamnionitis and preterm rupture of the membranes), clinical signs of infection, and serum C-reactive protein plasma level >10 mg/L.

  • Bronchopulmonary dysplasia defined as requiring additional oxygen at 36 weeks’ corrected postnatal gestational age and abnormal radiologic findings.25