TABLE 2.

Factors Associated with EV71 Infection in Preschool-Aged Children in Taiwan

FactorsSeropositive* (N = 484)Seronegative* (N = 1316)OR (95% CI)
Unadjusted ORAdjusted OR
Gender ratio (male/female)1.031.101.1 (0.85–1.3)
Age (mean ±SD)3.9 ± 1.72.6 ± 1.73.8 (3.0–4.7)2.5 (1.9–3.4)
Kindergarten/child care attendance57%29%3.3 (2.7–4.1)1.8 (1.3–2.5)
Contact history with HFMD/herpangina in 199823%16%1.6 (1.2–2.0)1.6 (1.2–2.1)
Number of children in a family (mean ±SD)2.5 ± 1.12.2 ± 1.11.6 (1.3–1.9)1.4 (1.1–1.7)
Living in a rural area55%40%1.4 (1.2–1.5)1.4 (1.2–1.6)
Classmates with HFMD/herpangina in 19986%4%1.6 (1.0–2.6)
Family member with HFMD/herpangina before 199813%10%1.4 (1.0–2.0)
Water supply (using tap water)74%69%1.3 (1.0–1.6)
Neighbors with HFMD/herpangina in 19988%6%1.3 (0.88–2.0)
Travel to high prevalence areas in 199827%23%1.2 (0.95–1.5)
Ever breastfed24%24%1.1 (0.93–1.3)
Cared for by babysitters6%7%1.1 (0.90–1.3)
  • * EV71 seropositive or seronegative after the 1998 epidemic.

  • OR was calculated using the seronegative children as a reference group. Unadjusted calculations were derived from univariate analyses. Adjusted OR resulted from multivariate analyses with a stepwise multiple logistic regression.