TABLE 3.

Regurgitation of Syrup and Vomiting Among Children 6 to 35 Months of Age in a Trial Evaluating 3 RDAs of Daily Zinc Administration as Treatment for Acute Diarrhea

VariableStudy Group
PlaceboZincVitamin A-ZincCaretaker-Zinc
Percentage of children with syrup regurgitation on enrollment day6.1*18.6*21.0*24.4
 Risk ratios (95% CI)13.1 (2.0,4.7)3.6 (2.4,5.4)4.0 (2.7,6.0)
  Infants4.616.920.923.6
 Risk ratios (95% CI)13.7 (1.7,7.8)4.6 (2.2,9.5)5.2 (2.5,10.6)
  Older than 12 mo7.019.721.125.1
 Risk ratios (95% CI)12.8 (1.7,4.6)3.0 (1.8,4.9)3.6 (2.2,5.8)
Percentage of days with syrup regurgitation after inclusion day0.9*3.8*3.8*5.8
 Risk ratios (95% CI)14.3 (2.8,6.6)4.0 (3.1,5.1)5.6 (4.4,7.2)
  Infants1.03.94.16.2
 Risk ratios (95% CI)13.9 (2.5,6.1)4.0 (2.6,6.34)6.1 (4.0,9.4)
  Older than 12 mo0.83.73.65.5
 Risk ratios (95% CI)14.4 (2.9,6.7)4.3 (2.8,6.5)6.6 (4.4,9.9)
Percentage of children with reported vomiting on enrollment day18.932.737.138.8
 Risk ratios (95% CI)11.7 (1.4,2.2)2.0 (1.6,2.5)2.1 (1.6,2.6)
Percentage of days during diarrhea with vomiting after enrollment day8.716.017.317.9
 Risk ratios (95% CI)11.8 (1.42,2.45)2.0 (1.6,2.6)2.0 (1.5,2.6)
  • CI indicates confidence interval.

  • * Children were observed for regurgitation and other adverse effects for 15 minutes after a field worker had given the zinc or the placebo syrup.