Table 3.

Effects of Metformin on Insulin Sensitivity

	Placebo		Metformin
	Initial	Final	Initial	Final
Minimal model
Insulin sensitivity^†	1.0 ± 0.2	1.2 ± 0.2	0.9 ± 0.2	1.2 ± 0.4
Glucose disposal^‡	0.018 ± 0.001	0.021 ± 0.002	0.022 ± 0.003	0.019 ± 0.001
Insulin/glucose
(μU/mL)/mg%	0.35 ± 0.03	0.29 ± 0.07	0.38 ± 0.05	0.25 ± 0.02^*
QUICKI
(1/[log insulin + log glucose])	0.30 ± 0.004	0.31 ± 0.006	0.30 ± 0.004	0.32 ± 0.004^*
HOMA-IR
(insulin × glucose/22.5)	96.3 ± 11.7	94.9 ± 30.6	119.5 ± 14.1	64.0 ± 5.2^*

↵* P < .01, metformin final versus metformin initial.
↵† Insulin sensitivity units = ×0.0001/minute/(μU/mL).
↵‡ Glucose disposal units = /minute.