Table 3.

Effects of Metformin on Insulin Sensitivity

PlaceboMetformin
InitialFinalInitialFinal
Minimal model
Insulin sensitivity 1.0 ± 0.21.2 ± 0.20.9 ± 0.21.2 ± 0.4
Glucose disposal 0.018 ± 0.0010.021 ± 0.0020.022 ± 0.0030.019 ± 0.001
Insulin/glucose
(μU/mL)/mg%0.35 ± 0.030.29 ± 0.070.38 ± 0.050.25 ± 0.02*
QUICKI
(1/[log insulin + log glucose])0.30 ± 0.0040.31 ± 0.0060.30 ± 0.0040.32 ± 0.004*
HOMA-IR
(insulin × glucose/22.5)96.3 ± 11.794.9 ± 30.6119.5 ± 14.164.0 ± 5.2*
  • * P < .01, metformin final versus metformin initial.

  • Insulin sensitivity units = ×0.0001/minute/(μU/mL).

  • Glucose disposal units = /minute.