Table 2.

Effects of Metformin on Various Biochemical Indices

PlaceboMetformin
InitialFinalInitialFinal
Insulin (μU/mL)28.0 ± 3.226.4 ± 7.731.5 ± 3.419.2 ± 1.5*
Glucose (mg%)77.2 ± 2.282.3 ± 2.784.9 ± 4.575.1 ± 1.6*
Leptin (ng/mL)
Males28.0 ± 3.324.7 ± 3.430.2 ± 2.031.6 ± 6.2
Females47.7 ± 7.4** 55.3 ± 10.957.0 ± 5.4** 53.8 ± 5.6
% change (females)16.2 ± 8.45.5 ± 6.73-165
HbA1c (%)5.5 ± 0.15.7 ± 0.15.6 ± 0.15.7 ± 0.1
IGF-I (ng/mL)453.3 ± 30.3461.6 ± 46.0406.8 ± 43.7411.1 ± 31.9
Lactate (mg%)1.3 ± 0.11.3 ± 0.11.3 ± 0.11.3 ± 0.1
Cholesterol (mg%)161.1 ± 10.4154.3 ± 9.8149.5 ± 6.0142.4 ± 5.2
LDL (mg%)101.7 ± 9.298.4 ± 7.693.7 ± 7.687.2 ± 4.8
HDL (mg%)38.3 ± 1.736.9 ± 1.637.6 ± 2.438.4 ± 2.4
LDL/HDL2.7 ± 0.22.7 ± 0.22.5 ± 0.22.3 ± 0.2
Triglycerides (mg%)109.4 ± 20.095.6 ± 21.686.4 ± 11.284.9 ± 9.9
  • Values are means ± standard error.

  • * P <. 02, metformin final versus metformin initial.

  • ** P < .02, females versus males.

  • F3-165 P < .05, metformin versus placebo.