Table 2.

Methodologic Quality of Included Trials

StudyInterventionAdequate Methods?
Case DefinitionDouble-Blinding
Danielsson50SimethiconeX
Sethi51SimethiconeX
Metcalf12SimethiconeXX
Illingworth53Dicyclomine
Grunseit54DicyclomineX
Weissbluth52DicyclomineX
Illingworth49Scopolamine
Evans57Dairy eliminationX
Hill58Hypoallergenic dietX
Forsyth59Hypoallergenic formulaX
Campbell56Soy formulaX
Lothe60Soy formula
Stahlberg62LactaseX
Miller61LactaseX
Treem55Fiber enrichmentXX
Barr64Increased carrying
Parkin9Increased carrying
Car ride simulator
X
Dihigo63Parent training
McKenzie11Decreased stimulation
Weizman65Herbal teaXX
Markestad10SucroseXX
Barr66SucroseXX
  • * All of the included trials were adequately randomized. Inadequate case definitions and study methods are discussed in the text.